By Robert K. Poole
First released in 1967, Advances in Microbial body structure is considered one of Elsevier's most famed and acclaimed sequence. Now edited by means of Professor Robert Poole, collage of Sheffield, Advances in Microbial body structure keeps to submit topical and demanding reports, studying body structure in its broadest context, to incorporate all fabric that contributes to our realizing of the way microorganisms and their part components paintings. themes comprise: * Glutathione, Altruistic Metabolite in Fungi * The function of the Flavodiiron Proteins in Microbial Nitric Oxide cleansing * rigidity Responsive micro organism: Biosensors as Environmental displays * Bacterial Na+ -or H+ - coupled ATP working at low electrochemical strength * Dissimiatory Fe(III) and Mn(IV) relief
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Additional info for Advances in Microbial Physiology, Vol. 49
Glutathione, Regulator of b-lactam Antibiotic Synthesis GSH shares structural similarities with the b-lactam biosynthetic intermediate d-(L-a-aminoadipyl)-L-cysteinyl-D-valine (ACV) – a tripeptide (Fig. 9), and it has been suggested that penicillin biosynthesis and GSH metabolism are interconnected in P. , 1999). , 2001). Thus, the pharmaceutical industry has had an interest to decrease intracellular GSH concentrations without inﬂuencing negatively the physiological status of the vegetative antibiotic-producing tissue.
Bioeng. 82, 691–801. , Giacco, M. and Testa di Ferro, M. 1|AF397211_, direct submission to database. , Nevrie, U. and Eckardt-Schupp, F. (1992) Use of batch and fed-batch fermentation for studies on the variation of glutathione content and its inﬂuence on the genotoxicity of methyl-nitro-nitrosoguanidine in yeast. Mutagenesis 7, 25–30. , Hadler, I. and Breitenbach, M. (1997) Identiﬁcation and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins.
2003). In ﬁssion yeast, the NADPH/GR system was the major one-electron Cr(VI) reductant 38 ISTVA´N PO´CSI, ROLF A. PRADE AND MICHEL J. , 2003). 6. 1. Nitrogen Starvation In S. cerevisiae cells exposed to nitrogen deprivation, about 90% of total GSH accumulated in the central vacuole and a transitory stimulation of GSH biosynthesis was also observed (Mehdi and Penninckx, 1997). The transient overproduction of GSH was inhibited by buthionine-(S,R)sulfoximine, a speciﬁc transition-state-analogue inhibitor of gGCS and was absent in a GSH-deﬁcient strain (Mehdi and Penninckx, 1997).