By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)
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01 ml of histamine (1 : 10000) was injected intracutaneously into the centres of the sites of application by means of a tuberculin syringe. After 15, 30, 60 and 90 min wheal and erythema sizes were determined planimetrically using a Tamaya digital planimeter, 27 Planix 7. The data obtained in this way were described by mean values plus standard deviations separately for pretreatment and time intervals. 05) therapeutic effects, tests following Newmann and Keuls were made. 20 sq cm) than in the reference areas, viz.
In: Urabe H, Zaiss N, Stettendorf S (eds) International antifungal symposium on bifonazole. Excerpta Medica, Amsterdam, 129 5. Plempel M (1983) Antimycotic efficacy of bifonazole in vitro and in vivo. Arzneimittelforsch 33: 517 52 Bifonazole in Dermatological Practice: Results of a Multicentre Study F. Saffe BAYER AG, Pharma Deutschland, Medizinisch-Wissenschaftliche Abteilung, 5090 Leverkusen, Bayerwerk, Federal Republic of Germany Abstract The desire to improve the therapeutic possibilities open to dermatologists in private practice and GPs has drawn attention increasingly to the problem of patient compliance.
53 Introduction Unlike the treatment of vaginal mycoses, the treatment of dermatomycoses has the disadvantage that the majority of therapeutic agents still require application for 4 to 6 weeks or longer, depending on the agent chosen. The result of this long duration oftherapy is inadequate compliance and, in consequence, premature termination of treatment and a high rate of recurrence. In a survey among dermatologists and patients, Meinhof et al. found that about 50% of patients paid no attention to medical directions about the frequency of application, 44% reduced the number of applications without being told to do so and 25% stopped treatment as soon as the symptoms had disappeared.