Asymmetric synthesis in organophosphorus chemistry: by Oleg I. Kolodiazhnyi

April 3, 2017 | Organic | By admin | 0 Comments

By Oleg I. Kolodiazhnyi

Authored through one of many major specialists within the box, this can be the single entire evaluation of chiral organophosphorus compounds, from uneven synthesis to catalysis and pharmacological applications.
As such, this targeted reference covers the chemical historical past in addition to spectroscopical research of phosphorus compounds, and carefully describes all of the numerous man made recommendations for those components. Metal-, organo- and biocatalyzed reactions for the advent of phosphorus are defined as are uneven oxidation and aid tools for the instruction of all attainable oxidation states of phosphorus. The textual content additionally contains commercial purposes for those compounds.
Of specific curiosity to chemists operating within the box of uneven synthesis, in addition to to the pharmaceutical as a result of expanding variety of phosphorous-containing medications

Show description

Read Online or Download Asymmetric synthesis in organophosphorus chemistry: synthetic methods, catalysis, and applications PDF

Similar organic books

Advances in Heterocyclic Chemistry

(from preface)Volume forty seven of Advances in Heterocyciic Chemistry is, in contrast to such a lot volumes, a monograph and bargains with the quantitative facets of electro-philic substitution of heterocycles. it's written by means of Roger Taylor of the collage of Sussex, Brighton, England, and your editor with one bankruptcy contributed through Ross Grimmett of the collage of Otago in New Zealand.

Chemistry of Heterocyclic Compounds: Thiophene and Its Derivatives, Part Two, Volume 44

Electrophilic Sustitution of Thiophene and Its Derivatives (R. Taylor). Alkylthiophenes and Their Reactions (P. Cagniant, et al. ). Halothiophenes and Their Reactions (M. G. Reinecke & P. Padaja). Nitrothiophenes and Their Reactions (R. ok. Norris). Aminothiophenes and Their Derivatives (R. ok. Norris).

Lewis Base Catalysis in Organic Synthesis, 3 Volume Set

Introductory expense £300 / €399 / $540, legitimate till December 31, 2016, thereafter £340 / €449 / $605This three-volume set represents the 1st accomplished assurance of the quickly increasing box of Lewis base catalysis that has attracted huge, immense consciousness lately. Lewis base catalysis is a conceptually novel paradigm that encompasses an incredibly large choice of preparatively precious differences and is very powerful for enantioselectively developing new stereogenic facilities.

Extra resources for Asymmetric synthesis in organophosphorus chemistry: synthetic methods, catalysis, and applications

Example text

The AC of α-hydroxyphosphonates can be determined by 1 H and 31 P NMR spectroscopy of the mandelate ester derivatives. The observed chemical shifts allow assignment of the AC of the hydroxyphosphonates depending on the position of the phenyl group in the compounds and its shielding effect. Thus, the 1 H NMR spectra of (1S,2R)-diastereomers showed a downfield shift of signals for the O-methyl protons relative to the parent alcohol. 13). 14 Determination of absolute configuration by derivatization of hydroxyphosphonates with MPA.

43, 665–668. , and Mastalerz, P. (1983) Determination of absolute configuration of optically active. 1 -aminoalkanephosphonic acids by chemical correlations. Phosphorus Sulfur Rel. , 18 (1-3), 393–396. , and Mikolajczyk, M. (2003) The first enzymatic desymmetrizations of prochiral phosphine oxides. Tetrahedron: Asymmetry, 14 (21), 3379–3384. , and Riguera, R. (2004) The assignment of absolute configuration by NMR. Chem. , 104 (1), 17–117. , and Kakisawa, H. (1991) Elucidation of the absolute configurations of amino acids and amines by the modified Mosher’s method.

2007) The chemistry of phosphinic and phosphinous acid derivatives containing t-butyl group as a single bulky substituent: synthetic, mechanistic and stereochemical aspects. Curr. Org. , 11 (1), 3–15. Börner, A. ) (2008) Phosphorus Ligands in Asymmetric Catalysis: Synthesis and Applications, vol. , 1546 pp. P. (1996) Basic terminology of stereochemistry (IUAC Recommendations 1996). Pure Appl. , 68 (12), 2193–2222. P. (1993) The CIP sequence rules: analysis and proposal for a revision. Tetrahedron: Asymmetry, 4 (4), 657–668.

Download PDF sample

Rated 4.17 of 5 – based on 7 votes