By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new gentle on bioactive fabrics from marine extremophiles. It offers with all features of the chemicals produced by way of organisms dwelling lower than severe stipulations which could have capability as medications or bring about novel medications for human use.
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Additional info for Bioactive Compounds from Marine Extremophiles
Eicosapentaenoic acid 179 is still being evaluated in several clinical studies. As of October 2014, the International Clinical Trials Registry Program has 22 trials listed as currently recruiting patients for treatment with either eicosapentaenoic acid alone or in combination with other fatty acids. The Department of Cardiology at Keio University School of Medicine is currently recruiting patients to evaluate the effects of compound 179 on left ventricular function in patients diagnosed with nonischemic cardiomyopathy (JPRN-UMIN000013609).
2012). The clinical effects of dietary ω-3 PUFAs from seafood-rich (mainly 20- and 22carbon fatty acids) diets on coronary atherosclerosis were ﬁrst reported in the 1970s. Dyerberg and coworkers performed a study on human subjects demonstrating that the enrichment of the linolenate-derived PUFA eicosapentaenoic acid (C20:5ω-3; 179) (Fig. 9) in lipid tissue may potentially reduce the development thrombosis and atherosclerosis (Dyerberg et al. 1978). This study was motivated by the rare incidence of cardiovascular disease among Eskimos, a population with high levels of eicosapentaenoic acid 179.
0 nM). 2 μM, respectively. The potent cytotoxicity and selectivity of compounds 126–128 suggest that they may inhibit the growth of tumor cells by a speciﬁc, unknown mechanism of action. , isolated a family of novel 2-alkylidene-5-alkyl-4-oxazolidones, the lipoxazolidinones, from another species of Marinispora (NPS008920 strain) (Macherla et al. 2007). This actinomycete was isolated from sediments collected in Cocos Lagoon, Guam. Lipoxazolidinones A–C (130–132) (Fig. 8) were determined to be oxazolidinones with varying alkyl chain lengths.