Biomarkers in Neoplastic Neuropathology by Fausto Rodriguez, Cheng-Ying Ho

April 3, 2017 | Anatomy | By admin | 0 Comments

By Fausto Rodriguez, Cheng-Ying Ho

This publication is a wealthy resource of knowledge on biomarkers acceptable to the pathology of neoplastic problems of the mind. Thorough descriptions are supplied of the suggestions at the moment to be had for scientific and experimental assessment of biomarkers in mind neoplasms, together with in situ hybridization, array-based equipment, methylation profiling, next-generation sequencing, and sensible gene panels. Incorporation of a number of biomarkers within the improvement of molecular subgroups with biologic and healing relevance can be mentioned. a bit on biobanking covers the both very important subject of optimum protection of tissue and comprises attention of moral concerns raised by means of tissue bought in medical settings. The last part discusses the key different types of neoplastic problems regarding the worried approach, with emphasis on diagnostic, prognostic, and predictive biomarkers utilized in the pathologic assessment of other kinds of mind tumor.

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Biomarkers in Neoplastic Neuropathology

This booklet is a wealthy resource of data on biomarkers acceptable to the pathology of neoplastic problems of the mind. Thorough descriptions are supplied of the options at the moment on hand for medical and experimental assessment of biomarkers in mind neoplasms, together with in situ hybridization, array-based equipment, methylation profiling, next-generation sequencing, and functional gene panels.

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Example text

Microdissection, followed by modified protein digestions and mass spectrometry, has found specific applications in the characterization of acellular proteinaceous deposits derived from immunoglobulin, such as amyloid [86]. Another elegant application of mass spectrometry and metabolomics to biomarker testing may be the identification of elevated 2-hydroxyglutarate levels, a universal feature of IDH mutant gliomas, in formalinfixed tumor tissues using gas chromatography followed by mass spectrometry [87].

Nowadays, most histology facilities utilize automated machines (“tissue processor”) to carry out tissue processing. Routine histologic examinations, such as a hematoxylin and eosin (H&E) stain, are recommended for every specimen before the tissue blocks are archived. From a quality control perspective, it is important to have pathologists’ professional oversight over the tissue harvesting process. Pathologists should ensure that the tissue harvested is lesional and of suitable quality for downstream assays.

Zuo T et al (2009) Methods in DNA methylation profiling. Epigenomics 1(2):331–345 69. Umer M, Herceg Z (2013) Deciphering the epigenetic code: an overview of DNA methylation analysis methods. Antioxid Redox Signal 18(15):1972–1986 70. Olkhov-Mitsel E, Bapat B (2012) Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers. Cancer Med 1(2):237–260 71. Irizarry RA et al (2008) Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res 18(5):780–790 72.

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