By Farshad Darvishi Harzevili
Due to its skill to degrade hydrophobic substrates hugely successfully, the non-conventional yeast Yarrowia lipolytica deals quite a few functions within the nutrition, feed, pharmaceutical, and tremendous chemistry industries, in addition to in environmental safeguard contexts resembling waste remedy and bioremediation.
The yeast breaks down hydrophobic substrates comparable to n-alkanes, fatty acids, fat, and oils, yielding beneficial biotechnological items corresponding to natural acids, extracellular enzymes, aroma compounds, bioemulsifiers, polyols, single-cell proteins, and single-cell oils. additional, Y. lipolytica is a good platform for the construction of assorted heterologous proteins; greater than 100 heterologous proteins – together with these of viruses, micro organism and fungi, in addition to plant, animal and human proteins – have already been produced in Y. lipolytica. on account that its genome has been sequenced, it really is now attainable to exploit new recombinant know-how and metabolic engineering which will enhance the metabolic pathways inquisitive about the construction of fascinating metabolites and products.
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Extra info for Biotechnological Applications of the Yeast Yarrowia lipolytica
Y. lipolytica is generally regarded as a biosafety class 1 microorganism. This biosafety class encompasses microorganisms which are not known to cause disease in healthy adult humans. The safety issues of Y. lipolytica were thoroughly evaluated and this yeast was labeled as a ‘‘safe-to-use’’ organism (Groenewald et al. 2014). The aspects regarding the safety of the yeast are evident because (i) it is inherently associated with dairy, poultry, and meat products, (ii) yeast biomass is a safe nutritional supplement, (iii) it is consumed as food and feed, and (iv) food-grade additives have been obtained from this yeast (Zinjarde 2014).
Terpenes biotransformation is an attractive alternative to production of aromas, because it occurs under mild conditions, does not generate toxic wastes, and allows producing ‘‘natural’’ aromas that can be used as fragrances and flavors in industry (de Carvalho and da Fonseca 2006; Trytek et al. 2009). Y. lipolytica is able convert R (+)-limonene into perillic acid. Perillic acid and its derivatives as terpenoid compounds are increasingly important due to their flavoring and antimicrobial properties as well as their potential as anticancer agents (Ferrara et al.
Finally, the x-oxidation will be also blocked to avoid the production of undesired dicarboxylic fatty acids. The resulting pool of fatty acids and fatty acid alcohols will be used for the production of wax esters (WEs), carotenoids, or carotenoid esters by expressing the corresponding bacterial biosynthetic genes (Sabirova et al. 2011). Reprinted with permission from John Wiley and Sons (license number: 3326191231944) Y. lipolytica has positive effect as ripening/maturation agent and/or negative effect as spoilage agent of food products.