By Christopher R. Cogle (auth.), Alison L. Allan (eds.)
The “cancer stem cellphone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the belief of melanoma stem cells has been round for greater than 100 years, facts from the fields of hematology and melanoma biology has now tested the serious function of stem cells in hematological malignancies and prompt that those related mechanisms also are vital to the initiation, development, and therapy of stable cancers. scientific and experimental experiences have proven that CSCs show many classical houses of standard stem cells, together with a excessive self-renewal means and the facility to generate heterogeneous lineages; the requirement for a selected “niche”/microenvironment to develop; and an elevated capability for self-protection opposed to harsh environments, pollution, and medication.
Cancer Stem Cells in stable Tumors represents an in depth evaluation of melanoma stem cells and their position in sturdy cancers. created from 24 chapters, this quantity will supply readers with a entire knowing of this significant and evolving field.
Topics coated include:
- Introduction of the CSC hypothesis
- Historical views and the contributing classes from leukemia
- Current wisdom in regards to the identity and position of CSCs in a variety of kinds of reliable melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
- Molecular pathways serious about using CSC functionality, with a selected concentrate on the radical convergence of embryonic and tumorigenic signaling pathways
- In vitro and in vivo assays, version structures, and imaging modalities for learning CSCs
- The scientific significance of CSCs for melanoma administration and therapy, together with very important implications for analysis, prediction, and therapy resistance
- Consideration of the talk surrounding the CSC speculation and critical unanswered questions during this field
This collective paintings was once written by way of a gaggle of renowned overseas specialists in melanoma biology, oncology, and/or stem mobile biology. it is going to function a useful source for validated researchers, professors, healthiness care pros, and scholars within the clinical and clinical neighborhood who're investigating stem cells and/or oncology.
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Extra resources for Cancer Stem Cells in Solid Tumors
Proia DA, Kuperwasser C (2006) Reconstruction of human mammary tissues in a mouse model. Nat Protoc 1 (1):206–214. 31 26. Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT, Eaves CJ (2008) A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 14 (12):1384 –1389. Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ (2009) Aberrant luminal progenitors as the candidate target population for basal tumor development in brca1 mutation carriers.
Nat Med 15 (8): 907–913. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G (2007) Aldh1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Moreb JS (2008) Aldehyde dehydrogenase as a marker for stem cells. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells.
Unlike pluripotent embryonic stem cells that are able to give rise to all cells of the body, these tissue-specific stem cells are multipotent – they are restricted to producing cells found within the breast tissue. 1 Support for Normal Murine Mammary Stem Cells The first evidence of a potential mammary stem cell was observed by Deome et al. . In their transplantation experiments, a sample of normal mammary tissue was implanted into a cleared mammary fat pad, resulting in outgrowths with normal mammary gland appearance.